San Francisco 49ers running back Isaac Guerendo (hamstring) was looking like a sure-fire league-winner after a highly ...

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until ...

The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ...

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

ESPN insider Adam Schefter reported that San Francisco 49ers rookie running back Isaac Guerendo is unlikely to play against ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...