San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

As the 49ers look to play spoiler against the Lions on Monday Night Football, RB Isaac Guerendo got a positive injury update.

With the exception of David Montgomery, the Lions had perfect practice attendance Saturday among players on the active roster ...

Best streaming services for Lions vs. 49ers. Detroit Lions vs. San Francisco 49ers will be aired locally in the Bay Area. It ...

The Detroit Lions visit the San Francisco 49ers on Monday at 8:15 p.m. ET, in a matchup featuring a pair of the best ...

It's a recipe that's as versatile as it is simple. Pair it with tortilla chips, quesadillas, tacos — whatever you want on ...

David Montgomery (knee) is the only player missing from the active roster. The starting running back remains in limbo, with ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's ...

Detroit Lions defensive coordinator Aaron Glenn called San Francisco 49ers TE George Kittle 'the best tight end in the game.' ...